Tg(EIF1AX-Aldh2*E487K)101Oht
Transgene Detail

Summary

• Symbol: Tg(EIF1AX-Aldh2*E487K)101Oht
• Name: transgene insertion 101, Shigeo Ohta
• MGI ID: MGI:5699091
• Synonyms: DAL101
• Transgene: Tg(EIF1AX-Aldh2*E487K)101Oht Location: unknown
• Alliance: Tg(EIF1AX-Aldh2*E487K)101Oht page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Single point mutation
• Tg(EIF1AX-Aldh2*E487K)101Oht expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Aldh2 (MGI:99600)

• Mutation details: The murine gene with a single point mutation of G to A in exon 12 that is confined to Asians and results in a substitution of glutamine 487 to lysine (E487K) is under the control of the human elongation factor-1 alpha. This mutation results in a dominant-negative effect. Three lines were established: DAL101, DAL102, and DAL103. DAL101 is the high expressing line. (J:137374)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:137374 Ohsawa I, et al., Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci. 2008 Jun 11;28(24):6239-49
• All: 3 reference(s)