Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:29218Analysis of male progeny from a (A/J x M. spretus)F1 x C57BL/6JBy backcross were analyzed. Interval mapping and quantitative trait linkage was used to map Pas1 to a 18 cM region on mouse Chromosome 6 between marker D6Mit12 and the cosegregating markers Kras, D6Mit14, D6Mit15 and D6Int1. 12.15.2015 Curator Note: Because Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Pas17. Susceptibility to lung carcinogenesis was attributed to the mice carrying the A/J allele. Pas17 peaked at Kras2 with a LOD score higher than 8.0; accounting for 34% of the total phenotypic variablity. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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