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Pas17A/J
QTL Variant Detail
Summary
QTL variant: Pas17A/J
Name: pulmonary adenoma susceptibility 17; A/J
MGI ID: MGI:5699133
QTL: Pas17  Location: Chr6:124334273-145601739 bp  Genetic Position: Chr6, Syntenic
Variant
origin
Strain of Specimen:  A/J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:29218

Analysis of male progeny from a (A/J x M. spretus)F1 x C57BL/6JBy backcross were analyzed. Interval mapping and quantitative trait linkage was used to map Pas1 to a 18 cM region on mouse Chromosome 6 between marker D6Mit12 and the cosegregating markers Kras, D6Mit14, D6Mit15 and D6Int1.

12.15.2015 Curator Note: Because Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Pas17.

Susceptibility to lung carcinogenesis was attributed to the mice carrying the A/J allele. Pas17 peaked at Kras2 with a LOD score higher than 8.0; accounting for 34% of the total phenotypic variablity.

References
Original:  J:29218 Manenti G, et al., Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2. Genomics. 1995 Sep 20;29(2):438-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory