Tg(SOD1*H46R)LAra
Transgene Detail

Summary

• Symbol: Tg(SOD1*H46R)LAra
• Name: transgene insertion L, Toshiyuki Araki
• MGI ID: MGI:5699326
• Synonyms: H46R (L)
• Transgene: Tg(SOD1*H46R)LAra Location: unknown
• Alliance: Tg(SOD1*H46R)LAra page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 12 kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine. Nine lines were established, including lines H, I, and L. This line has 39-49 copy numbers of the transgene. (J:221350)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:221350 Nagano S, et al., A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS. Hum Mol Genet. 2015 Jun 15;24(12):3427-39
• All: 1 reference(s)