Tg(SOD1*H46R*C111S)PAra
Transgene Detail

Summary

• Symbol: Tg(SOD1*H46R*C111S)PAra
• Name: transgene insertion P, Toshiyuki Araki
• MGI ID: MGI:5699338
• Synonyms: H46R/C111S (P)
• Transgene: Tg(SOD1*H46R*C111S)PAra Location: unknown
• Alliance: Tg(SOD1*H46R*C111S)PAra page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*H46R*C111S)PAra expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: A 12 kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine and the cysteine residue at position 111 was replaced by serine. Five lines were established, including lines N, P, and Q. This line has 24-36 copy numbers of the transgene. (J:221350)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:221350 Nagano S, et al., A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS. Hum Mol Genet. 2015 Jun 15;24(12):3427-39
• All: 1 reference(s)