Tg(Chek1)1Ofc
Transgene Detail

Summary

• Symbol: Tg(Chek1)1Ofc
• Name: transgene insertion 1, Oscar Fernandez-Capetillo
• MGI ID: MGI:5699590
• Synonyms: Chek1^Tg, Tg(Chek1)Ofc, Tg.Chek1(Rp23-318C6)
• Transgene: Tg(Chek1)1Ofc Location: unknown
• Alliance: Tg(Chek1)1Ofc page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Chek1)1Ofc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Chek1 (MGI:1202065)

• Mutation details: A 33.5-kb DNA segment containing the mouse checkpoint kinase 1 (Chek1) gene and 5' and 3' flanking sequences extending to the next conserved gene in either direction was subcloned into a minimal vector, which was then linearized for microinjection into fertilized oocytes. Southern blot analysis revealed that one line had integrated a single copy of the transgene. (J:182697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:182697 Lopez-Contreras AJ, et al., An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation. J Exp Med. 2012 Mar 12;209(3):455-61
• All: 4 reference(s)