Aasdhppt^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Aasdhppt^{tm1.1(KOMP)Vlcg}
• Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5700041
• Synonyms: Aasdhppt^-
• Gene: Aasdhppt Location: Chr9:4294793-4309471 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Aasdhppt^{tm1.1(KOMP)Vlcg} page
• IMPC: Aasdhppt gene page

Aasdhppt^{tm1.1(KOMP)Vlcg}/Aasdhppt^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form typical outgrowths.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 13348A-C10
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: Cre-mediated excision of the parental Aasdhppt^{tm1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aasdhppt Mutation: 13 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 4 reference(s)