Tg(Six1-cre)2Kwk
Transgene Detail

Summary

• Symbol: Tg(Six1-cre)2Kwk
• Name: transgene insertion 2, Kiyoshi Kawakami
• MGI ID: MGI:5700048
• Synonyms: mSix1-8-NLSCre, Six1enh8-Cre, Tg(Six1-enh8-cre)2Kwk
• Transgene: Tg(Six1-cre)2Kwk Location: unknown
• Alliance: Tg(Six1-cre)2Kwk page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Six1-cre)2Kwk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Six1

• Mutation details: The transgene contains the sensory ganglion-specific enhancer of the Six1 homeobox gene (Six1enh8), the HSV thymidine kinase gene promoter, a chimeric intron a cre recombinase gene with a nuclear localization signal that are flanked by two tandem copies of the core region of the HS4 insulator. Lines 22L, 30L, 31L, 32L, 33L, 7l and 35l were generated. Line 35l is also designated as line 2 and was selected as the representative line. (J:227250)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Six1 (species not specified) Summary of all recombinase alleles driven by Six1. Comparative matrix view of recombinase activities
User Notes:	Additional information submitted by the research community Additional information submitted by the research community Some E9.0 to E12.5 embryos exhibit variable ubiquitous reporter recombinase staining in addition to the specific pattern indicating a burst of ubiquitous expression. J:227250

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:227250 Sato S, et al., Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS One. 2015;10(8):e0136666
• All: 1 reference(s)