Topaz1^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Topaz1^tm1Ics
• Name: testis and ovary specific PAZ domain containing 1; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:5700076
• Gene: Topaz1 Location: Chr9:122576411-122631200 bp, + strand Genetic Position: Chr9, 73.1 cM
• Alliance: Topaz1^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226405
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The lacZ gene and floxed neomycin resistance cassette replaced exons 1 and 2. QRT-PCR confirmed the absence of transcript expression in mice at P5, P10, P15, P28, P42 and adult stages. (J:226405)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Topaz1 Mutation: 68 strains or lines available

References

• Original: J:226405 Luangpraseuth-Prosper A, et al., TOPAZ1, a germ cell specific factor, is essential for male meiotic progression. Dev Biol. 2015 Oct 15;406(2):158-71
• All: 2 reference(s)