Tg(Plp1-HTT*150Q)4aXjl
Transgene Detail

Summary

• Symbol: Tg(Plp1-HTT*150Q)4aXjl
• Name: transgene insertion 4a, Xiao-Jiang Li
• MGI ID: MGI:5700344
• Synonyms: PLP-150Q
• Transgene: Tg(Plp1-HTT*150Q)4aXjl Location: unknown
• Alliance: Tg(Plp1-HTT*150Q)4aXjl page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Plp1-HTT*150Q)4aXjl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: Expression of a cDNA encoding N-terminal human HTT (amino acids 1-212) containing 150 glutamines in the repeat region (150Q) is under the control of the oligodendrocyte specific murine Plp1 promoter. Western blot confirmed formation of aggregated HTT in the brain and selective expression in the brain stem, striatum, and corpus callosum. (J:221608)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:221608 Huang B, et al., Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 2015 Mar 18;85(6):1212-26
• All: 2 reference(s)