Lzts1^tm1Kso
Targeted Allele Detail

Summary

• Symbol: Lzts1^tm1Kso
• Name: leucine zipper, putative tumor suppressor 1; targeted mutation 1, Kenji Sobue
• MGI ID: MGI:5700365
• Synonyms: PSD-Zip70 KO
• Gene: Lzts1 Location: Chr8:69585321-69636877 bp, - strand Genetic Position: Chr8, 33.88 cM
• Alliance: Lzts1^tm1Kso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226686
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 1-2 and part of exon 3. All of the coding regions of the gene are deleted. RT-PCR analysis on RNA derived from homozygous mutant prefrontal cortex and hippocampus showed that no detectable transcript is expressed from this allele. Likewise, western blot analysis on the same tissues demonstrated a lack of encoded protein compared to control tissues. (J:226686)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lzts1 Mutation: 23 strains or lines available

References

• Original: J:226686 Mayanagi T, et al., PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci. 2015 Oct 21;35(42):14327-40
• All: 2 reference(s)