Ltk^tm1Rabr
Targeted Allele Detail

Summary

• Symbol: Ltk^tm1Rabr
• Name: leukocyte tyrosine kinase; targeted mutation 1, Jacob Raber
• MGI ID: MGI:5700379
• Gene: Ltk Location: Chr2:119581807-119590912 bp, - strand Genetic Position: Chr2, 59.97 cM
• Alliance: Ltk^tm1Rabr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226591
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 10 and 11 are deleted, encoding a total of 66 amino acids. The protein domains deleted include the entire transmembrane domain required for anchoring the mature receptor in the plasma membrane. (J:226591)

Expression

In Mice Carrying this Mutation:

21 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltk Mutation: 26 strains or lines available

References

• Original: J:226591 Weiss JB, et al., Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis. Pharmacol Biochem Behav. 2012 Jan;100(3):566-74
• All: 2 reference(s)