S1pr3^tm1.1Hrose
Targeted Allele Detail

Summary

• Symbol: S1pr3^tm1.1Hrose
• Name: sphingosine-1-phosphate receptor 3; targeted mutation 1.1, Hugh Rosen
• MGI ID: MGI:5701466
• Synonyms: S1P3-mCherry
• Gene: S1pr3 Location: Chr13:51562675-51576833 bp, + strand Genetic Position: Chr13, 26.12 cM, cytoband B1
• Alliance: S1pr3^tm1.1Hrose page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227542
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a monomeric red fluorescent protein (mCherry) gene and an loxP-flanked ACN cassette downstream of the coding region of the gene. Cre-mediated recombination removed the cassette leaving a single loxP site downstream of the coding region. (J:227542)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr3 Mutation: 24 strains or lines available

References

• Original: J:227542 Sanna MG, et al., Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016 Jan;89(1):176-86
• All: 3 reference(s)