Cidec^tm1.2Gonz
Targeted Allele Detail

Summary

• Symbol: Cidec^tm1.2Gonz
• Name: cell death-inducing DFFA-like effector c; targeted mutation 1.2, Frank Gonzalez
• MGI ID: MGI:5701689
• Synonyms: Fsp27^deltaAd
• Gene: Cidec Location: Chr6:113401595-113412721 bp, - strand Genetic Position: Chr6, 52.76 cM, cytoband E3
• Alliance: Cidec^tm1.2Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226899
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector contains a loxP site upstream of exon 2 and an FRT-flanked neomycin selection cassette followed by a second loxP site downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 2 and 3 floxed. Cre-mediated recombination removed the exons 2 and 3. (J:226899)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cidec Mutation: 15 strains or lines available

References

• Original: J:226899 Tanaka N, et al., Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice. J Biol Chem. 2015 Jan 30;290(5):3092-105
• All: 1 reference(s)