Ctsd^tm1.1Thre
Targeted Allele Detail

Summary

• Symbol: Ctsd^tm1.1Thre
• Name: cathepsin D; targeted mutation 1.1, Thomas Reinheckel
• MGI ID: MGI:5702318
• Synonyms: Ctsd^flox
• Gene: Ctsd Location: Chr7:141929647-141941564 bp, - strand Genetic Position: Chr7, 87.93 cM
• Alliance: Ctsd^tm1.1Thre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector containing a loxP-flanked exon 2 of and an FRT-flanked puromycin selection cassette was intregrated into the locus by homologous recombination. Subsequently, the selection cassette was removed by flpe recombination. (J:227618)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsd Mutation: 19 strains or lines available

References

• Original: J:227618 Ketscher A, et al., Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10. Biochimie. 2016 Mar;122:219-26
• All: 4 reference(s)