Mir182^tm1.1Dgk
Targeted Allele Detail

Summary

• Symbol: Mir182^tm1.1Dgk
• Name: microRNA 182; targeted mutation 1.1, David Kirsch
• MGI ID: MGI:5702430
• Synonyms: miR-182-flox
• Gene: Mir182 Location: Chr6:30165917-30165991 bp, - strand Genetic Position: Chr6, 12.52 cM
• Alliance: Mir182^tm1.1Dgk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217635
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of the Mir182 coding region and a FRT-flanked neomycin resistance (neo) cassette downstream of the coding region followed by a second loxP site. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:217635)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir182 Mutation: 8 strains or lines available

References

• Original: J:217635 Sachdeva M, et al., MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. J Clin Invest. 2014 Oct;124(10):4305-19
• All: 5 reference(s)