Gas7^tm1Slch
Targeted Allele Detail

Summary

• Symbol: Gas7^tm1Slch
• Name: growth arrest specific 7; targeted mutation 1, Sue Lin-Chao
• MGI ID: MGI:5702632
• Synonyms: gas7^m
• Gene: Gas7 Location: Chr11:67345917-67575800 bp, + strand Genetic Position: Chr11, 41.13 cM
• Alliance: Gas7^tm1Slch page

The number of motor neurons is decreased in old Gas7^tm1Slch/Gas7^tm1Slch mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227375
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Hypomorph) Mutation: Insertion Mutation details: A neomycin resistance cassette with a loxP site and stop codons was inserted into exon 6b. Western blot analysis confirmed the absence of full-length protein and low level expression of a truncated protein. A protein degradation assay revealed that the expressed mutant protein is more easily degraded than the wild-type in primary cortical cultured neurons from E16.5 wild-type and homozygous mutant mice. (J:227375)

Generation of the Gas7^tm1Slch allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gas7 Mutation: 24 strains or lines available

References

• Original: J:227375 Huang BT, et al., Gas7-deficient mouse reveals roles in motor function and muscle fiber composition during aging. PLoS One. 2012;7(5):e37702
• All: 1 reference(s)