Pde6h^tm1.1Bewi
Targeted Allele Detail

Summary

• Symbol: Pde6h^tm1.1Bewi
• Name: phosphodiesterase 6H, cGMP-specific, cone, gamma; targeted mutation 1.1, Bernd Wissinger
• MGI ID: MGI:5702758
• Synonyms: L1
• Gene: Pde6h Location: Chr6:136929216-136940483 bp, + strand Genetic Position: Chr6, 66.72 cM
• Alliance: Pde6h^tm1.1Bewi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222177
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the loxP flanked exons 2-4 and the Neo/TK selection cassette. Immunofluorescence analysis confirmed absence of protein in the retina. (J:222177)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde6h Mutation: 11 strains or lines available

References

• Original: J:222177 Brennenstuhl C, et al., Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory. J Biol Chem. 2015 Apr 17;290(16):10242-55
• All: 1 reference(s)