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Chol16AKR/J
QTL Variant Detail
Summary
QTL variant: Chol16AKR/J
Name: cholesterol 16; AKR/J
MGI ID: MGI:5703025
Synonyms: Chol16AKR.129P2(B6)-Apoe-tm1Bres
QTL: Chol16  Location: Chr10:35915043-35915043 bp  Genetic Position: Chr10, Syntenic
Variant
origin
Strain of Specimen:  AKR/J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:106112

Linkage analysis was performed on 209 (AKR.129P2(B6)-Apoetm1Bres x D2.129P2(B6)-Apoetm1Bres)F2 intercross mice (95 female, 114 male) using 1967 markers. The cross was generated to identify QTL related to atherosclerosis. Parental strains AKR/J and DBA/2J are atherosclerosis resistant and sensitive, respectively. Additional QTL were identified for body weight; total cholesterol and blood count parameters. Genome-wide probability values were assigned as p0.05 =significant; p<0.25 = likely, and p.025 as suggestive.

Total cholesterol QTL were identified on Chromosomes 10 and 13.

A significant male specific QTL, Chol15, cholesterol 15, mapped to mouse chromosome 13 with peak marker rs6244558 with a LOD=3.85, p<0.05. DBA/2J alleles conferred higher cholesterol at this locus.

QTL Chol18, cholesterol 18, in both sexes combined, mapped to Chromosome 13 with peak marker rs6244558 with a LOD=4.67, p<0.15. DBA/2J alleles conferred higher cholesterol at this locus in a single sex analysis.

QTL Chol16, cholesterol 16, also male specific mapped to Chromosome 10 with peak marker rs13459120 with a LOD=3.47, p<0.10. The AKR/J alleles conferred higher cholesterol at this locus.

A significant male specific QTL, Wbc1, white blood count 1, mapped to Chromosome 8 to peak marker rs13479943 with a LOD=4.05, p<0.05.

Wbc2, white blood cell count 2, mapped in both sexes also mapped to Chromosome 8, peaking at marker rs13479941 with a LOD=6.22, p<0.01.

A significant QTL, Rbc1, red blood cell count 1, mapped in both male and female mice mapped to Chromosome 4, peaking at marker rs3657938 with a LOD=4.67, p<0.05.

A QTL, Mono1, monocyte differential 1, mapped in both sexes, mapped to Chromosome 5, peaking at marker rs6370004 with a LOD=3.01, p<0.25.

A QTL, Hct1, hematocrit 1, mapped in both sexes, mapped to Chromosome 4, peaking at marker, rs3657938 with a LOD=3.89, p<0.10.

A QTL Hgb1, hemaglobin 1, also mapped in both sexes to Chromosome 4, peaking at marker rs3657938 with a LOD=3.97, p<0.10.

QTL Hgb2, hemaglobin 2, also mapped in both sexes, mapped to chromosome 14, LOD=3.17 at marker rs13482409, p<0.20.

QTL Lymph1, lymphocyte differential 1, a male specific QTL, mapped to Chromosome 2 peaking at marker rs13476557 with a LOD=3.28, p<0.15. AKR/J alleles confer an increased percentage of lymphocytes at this locus.

QTL Lymph2, lymphocyte differential 2, also male specific, mapped to Chromosome 17 peaking at maker rs13483042 with a LOD=3.07, p<0.25. DBA/2J alleles confer and increased percentage of lymphocytes at this locus.

QTL Lymph3, lymphocyte differential 3, also male specific, mapped to Chromosome 4 peaking at marker rs8260738 with a LOD=3.01, p<0.25. DBA/2J alleles confer and increased percentage of lymphocytes at this locus.

QTL Lymph4, lymphocyte differential 4, mapped in both sexes to Chromosome 17 at peak marker rs13483042 with a LOD=3.69, p<0.10. DBA/2J alleles confer and increased percentage of lymphocytes at this locus.

QTL Lymph5, lymphocyte differential 5, also mapped in both sexes to Chromosome 2 at peak marker rs13476534 with a LOD=3.05, p<0.25.AKR/J alleles confer an increased percentage of lymphocytes at this locus.

References
Original:  J:106112 Smith JD, et al., Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):597-603
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory