Procr^{tm1.1(cre/ERT2)Yaz}
Targeted Allele Detail

Summary

• Symbol: Procr^{tm1.1(cre/ERT2)Yaz}
• Name: protein C receptor, endothelial; targeted mutation 1.1, Yi Arial Zeng
• MGI ID: MGI:5703644
• Synonyms: Procr^CreERT2, Procr^{CreERT2-IRES-tdTomato}
• Gene: Procr Location: Chr2:155593037-155597391 bp, + strand Genetic Position: Chr2, 77.26 cM, cytoband H1-3
• Alliance: Procr^{tm1.1(cre/ERT2)Yaz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217483
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Procr^{tm1.1(cre/ERT2)Yaz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Procr (MGI:104596)

• Mutation details: An inducible cre recombinase fusion gene (cre/ERT2), IRES, tdTomato reporter gene and FRT-flanked neomycin resistance cassette were inserted at the translation initiation site. Flp-mediated recombination removed the selection cassette. (J:217483)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Procr (mouse) Summary of all recombinase alleles driven by Procr. Comparative matrix view of recombinase activities Alliance mouse Procr gene page

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Procr Mutation: 17 strains or lines available

References

• Original: J:217483 Wang D, et al., Identification of multipotent mammary stem cells by protein C receptor expression. Nature. 2015 Jan 1;517(7532):81-4
• All: 6 reference(s)