Dp(16Mis18a-Runx1)2TybEmcf
Targeted Allele Detail

Summary

• Symbol: Dp(16Mis18a-Runx1)2TybEmcf
• Name: duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 2
• MGI ID: MGI:5703800
• Synonyms: Dp(16)2TybEmcf, Dp2Tyb
• Gene: Dp(16Mis18a-Runx1)2TybEmcf Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227899
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutation: Duplication
• Dp(16Mis18a-Runx1)2TybEmcf involves 80 genes/genome features (Gm30342, Gm27773, Gm22933 ...) View all
• Mutation details: MICER vectors MHPP323h04 (16:90563769-16:90577148 Mb; mouse assembly GRCm38/mm10) and MHPN219i02 (16:93054020-16:93062456 Mb) introduced loxP sites proximal to Mis18a and distal to Runx1. Cre-mediated recombination duplicated the sequence floxed by loxP sites. (J:227899)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dp(16Mis18a-Runx1)2TybEmcf Mutation: 3 strains or lines available

References

• Original: J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
• All: 4 reference(s)