Dp(16Dyrk1a-B3galt5)5TybEmcf
Targeted Allele Detail

Summary

• Symbol: Dp(16Dyrk1a-B3galt5)5TybEmcf
• Name: duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 5
• MGI ID: MGI:5703806
• Synonyms: Dp(16)5TybEmcf, Dp5Tyb
• Gene: Dp(16Dyrk1a-B3galt5)5TybEmcf Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227899
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutations: Duplication, Insertion
• Dp(16Dyrk1a-B3galt5)5TybEmcf involves 38 genes/genome features (Gm22745, Gm15317, Gm15341 ...) View all
• Mutation details: MICER vectors MHPP432c09 (16:94538615-16:94546849 Mb; mouse assembly GRCm38/mm10) located between Dscr3 and Dyrk1a and MHPN235b18 (16:96327324-16:96331804 Mb) located between B3galt5 and Igsf5 were subjected to cre-mediated recombination to duplicate the sequence flanked by loxP sites. (J:227899)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dp(16Dyrk1a-B3galt5)5TybEmcf Mutation: 1 strain or line available

References

• Original: J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
• All: 3 reference(s)