Dp(16Igsf5-Zbtb21)6TybEmcf
Targeted Allele Detail

Summary

• Symbol: Dp(16Igsf5-Zbtb21)6TybEmcf
• Name: duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 6
• MGI ID: MGI:5703808
• Synonyms: Dp(16)6TybEmcf, Dp6Tyb
• Gene: Dp(16Igsf5-Zbtb21)6TybEmcf Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227899
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutations: Duplication, Insertion
• Dp(16Igsf5-Zbtb21)6TybEmcf involves 25 genes/genome features (Gm24777, Gm41511, Gm41514 ...) View all
• Mutation details: MICER vectors MHPN235b18 (16:96327324-16:96331804 Mb) located between B3galt5 and Igsf5 and MHPN352i16 (16:97977263-16:97982380 Mb) were used to insert loxP sites proximal to Igsf5 and distal to Zbtb21. Cre-mediated recombination duplicated the sequence floxed by loxP sites. (J:227899)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dp(16Igsf5-Zbtb21)6TybEmcf Mutation: 2 strains or lines available

References

• Original: J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
• All: 3 reference(s)