Apoe^tm1.1Mae
Targeted Allele Detail

Summary

• Symbol: Apoe^tm1.1Mae
• Name: apolipoprotein E; targeted mutation 1.1, Nobuyo Maeda
• MGI ID: MGI:5703874
• Synonyms: Apoe^flox
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^tm1.1Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219838
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP site and an FRT-flanked neo cassette inserted downstream of exon 3 of the targeted gene, and another loxP site inserted upstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 3 floxed. (J:219838)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 158 strains or lines available

References

• Original: J:219838 Huang ZH, et al., Selective suppression of adipose tissue apoE expression impacts systemic metabolic phenotype and adipose tissue inflammation. J Lipid Res. 2015 Feb;56(2):215-26
• All: 5 reference(s)