Smc2^tm1.1Hiran
Targeted Allele Detail

Summary

• Symbol: Smc2^tm1.1Hiran
• Name: structural maintenance of chromosomes 2; targeted mutation 1.1, Tatsuya Hirano
• MGI ID: MGI:5703878
• Synonyms: Smc2^flox, Smc2^tm1.1Itl
• Gene: Smc2 Location: Chr4:52439243-52488260 bp, + strand Genetic Position: Chr4, 28.31 cM, cytoband B3
• Alliance: Smc2^tm1.1Hiran page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222181
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A frt site, a loxP site, a neomycin selection cassette, a frt site, and a loxP site upstream of exon 10 and a loxP site downstream of exon 12 were inserted via homologous recombination. The neomycin selection cassette was removed via flp-mediated recombination. (J:222181)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smc2 Mutation: 52 strains or lines available

References

• Original: J:222181 Nishide K, et al., Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet. 2014 Dec;10(12):e1004847
• All: 2 reference(s)