Appl2^tm1.1Test
Targeted Allele Detail

Summary

• Symbol: Appl2^tm1.1Test
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; targeted mutation 1.1, Joseph Testa
• MGI ID: MGI:5703918
• Synonyms: Appl2^-
• Gene: Appl2 Location: Chr10:83435897-83484602 bp, - strand Genetic Position: Chr10, 41.29 cM
• Alliance: Appl2^tm1.1Test page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227340
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette and a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed the selection cassette and exon 5. Western blot analysis confirmed the absence of protein expression in the liver and heart. (J:227340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Appl2 Mutation: 27 strains or lines available

References

• Original: J:227340 Tan Y, et al., Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. J Cell Physiol. 2016 May;231(5):1142-50
• All: 1 reference(s)