Cxxc5^tm1Kych
Targeted Allele Detail

Summary

• Symbol: Cxxc5^tm1Kych
• Name: CXXC finger 5; targeted mutation 1, Kang-Yell Choi
• MGI ID: MGI:5703924
• Gene: Cxxc5 Location: Chr18:35962450-35994741 bp, + strand Genetic Position: Chr18, 19.26 cM, cytoband B3
• Alliance: Cxxc5^tm1Kych page

High bone mass phenotype in Cxxc5^tm1Kych/Cxxc5^tm1Kych mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226604
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced exon 2 which contains the ATG start codon. Immunohistochemistry confirmed the absence of protein expression in adult homozygous mutant tissues, including kidney tissue. (J:226362, J:226604)

Generation of the Cxxc5^tm1Kych allele

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxxc5 Mutation: 52 strains or lines available

References

• Original: J:226604 Kim HY, et al., CXXC5 is a negative-feedback regulator of the Wnt/beta-catenin pathway involved in osteoblast differentiation. Cell Death Differ. 2015 Jun;22(6):912-20
• All: 11 reference(s)