Mc4r^tm1.1Fbz
Targeted Allele Detail

Summary

• Symbol: Mc4r^tm1.1Fbz
• Name: melanocortin 4 receptor; targeted mutation 1.1, Florian Bolze
• MGI ID: MGI:5703936
• Synonyms: Mc4r^X16
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^tm1.1Fbz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225022
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct introduced the substitution of a termination codon for tryptophan at position 16 (W16X). Cre-mediated recombination removed the floxed neomycin resistance cassette introduced downstream of the coding sequence. (J:225022)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 48 strains or lines available

References

• Original: J:225022 Bolze F, et al., Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo. Pharmacogenomics J. 2013 Feb;13(1):80-93
• All: 1 reference(s)