Gdf2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Gdf2^tm1Lex
• Name: growth differentiation factor 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5703975
• Synonyms: Bmp9^-, BMP9 KO
• Gene: Gdf2 Location: Chr14:33662996-33669155 bp, + strand Genetic Position: Chr14, 20.8 cM
• Alliance: Gdf2^tm1Lex page

Neutralization of BMP10 causes defective vascular development in Gdf2^tm1Lex/Gdf2⁺ and Gdf2^tm1Lex/Gdf2^tm1Lex mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222016
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion A beta-geo and puromycin resistance cassette replaced exon 2, encoding the receptor binding domain. (J:222016)

Generation of the Gdf2^tm1Lex allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gdf2 Mutation: 25 strains or lines available

References

• Original: J:222016 Chen H, et al., Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11887-92
• All: 1 reference(s)