Bmp10^{tm1.1(Gdf2)Minh}
Targeted Allele Detail

Summary

• Symbol: Bmp10^{tm1.1(Gdf2)Minh}
• Name: bone morphogenetic protein 10; targeted mutation 1.1, Minhong Yan
• MGI ID: MGI:5703977
• Synonyms: Bmp10⁹
• Gene: Bmp10 Location: Chr6:87405976-87411494 bp, + strand Genetic Position: Chr6, 37.96 cM, cytoband D2
• Alliance: Bmp10^{tm1.1(Gdf2)Minh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222016
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Bmp10^{tm1.1(Gdf2)Minh} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gdf2 (MGI:1321394)

• Mutation details: Exons 1 and 2 were replaced with the corresponding sequence from Gdf2. A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. (J:222016)

Generation of the Bmp10^{tm1.1(Gdf2)Minh} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp10 Mutation: 23 strains or lines available

References

• Original: J:222016 Chen H, et al., Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11887-92
• All: 1 reference(s)