Gabrb1^m1Qnma
Chemically induced Allele Detail

Summary

• Symbol: Gabrb1^m1Qnma
• Name: gamma-aminobutyric acid type A receptor subunit beta 1; mutation 1, Quentin M Anstee
• MGI ID: MGI:5704358
• Synonyms: Gabrb1^L285R
• Gene: Gabrb1 Location: Chr5:71815456-72306380 bp, + strand Genetic Position: Chr5, 38.18 cM
• Alliance: Gabrb1^m1Qnma page

Mutation origin

• Strain of Origin: BALB/cAnN

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to G point mutation in exon 8 that results in the amino acid substitution of leucine with arginine at position 310 (p.L310R or p.L285R on mature peptide). (J:223500)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabrb1 Mutation: 28 strains or lines available

References

• Original: J:223500 Anstee QM, et al., Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat Commun. 2013;4:2816
• All: 1 reference(s)