Fancm^Chaos4
Chemically induced Allele Detail

Summary

• Symbol: Fancm^Chaos4
• Name: Fanconi anemia, complementation group M; chromosome aberrations occurring spontaneously 4
• MGI ID: MGI:5704402
• Synonyms: Fancm^C4
• Gene: Fancm Location: Chr12:65122377-65178832 bp, + strand Genetic Position: Chr12, 27.21 cM
• Alliance: Fancm^Chaos4 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion was identified as a de novo T-to-C transition at nucleotide 524 of the coding region. This point mutation changes a highly conserved cysteine residue to arginine (C142A) that is located within the DEXDc domain of this DEAD-like helicase. (J:228047)

Expression

In Mice Carrying this Mutation:

4 assay results

Tumor Data

List all tumor models in MMHCdb carrying Fancm^Chaos4

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancm Mutation: 119 strains or lines available

References

• Original: J:228047 Luo Y, et al., Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling. PLoS Genet. 2014 Jul;10(7):e1004471
• All: 2 reference(s)