Tg(Prnp-ATXN7*92Q)6529Als
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATXN7*92Q)6529Als
• Name: transgene insertion 6529, Albert R La Spada
• MGI ID: MGI:5704405
• Synonyms: PrP-SCA7-c92Q
• Transgene: Tg(Prnp-ATXN7*92Q)6529Als Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(Prnp-ATXN7*92Q)6529Als page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATXN7*92Q)6529Als expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN7 (6314)

  Atxn7

  (MGI:2179277)

• Mutation details: The coding region of human ATXN7, containing 92 CAG repeats is under the control of the murine prion protein promoter. This line integrated into the X chromosome and is a low expressor. (J:71971, J:135615)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:71971 La Spada AR, et al., Polyglutamine-expanded ataxin-7 antagonizes crx function and induces cone-rod dystrophy in a mouse model of sca7. (Erratum: Neuron 2001;32:957). Neuron. 2001 Sep 27;31(6):913-27
• All: 3 reference(s)