Gdap1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Gdap1^tm1.1Ics
• Name: ganglioside-induced differentiation-associated-protein 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5704443
• Gene: Gdap1 Location: Chr1:17215586-17234495 bp, + strand Genetic Position: Chr1, 5.21 cM, cytoband A4
• Alliance: Gdap1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221297
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed floxed exon 5. Western blot analysis confirmed the absence of protein expression. (J:221297)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdap1 Mutation: 23 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Charcot-Marie-Tooth Disease J:221297.

References

• Original: J:221297 Niemann A, et al., The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease. Brain. 2014 Mar;137(Pt 3):668-82
• All: 1 reference(s)