Irs4^tm1.1Mfw
Targeted Allele Detail

Summary

• Symbol: Irs4^tm1.1Mfw
• Name: insulin receptor substrate 4; targeted mutation 1.1, Morris F White
• MGI ID: MGI:5705105
• Gene: Irs4 Location: ChrX:140493994-140508213 bp, - strand Genetic Position: ChrX, 62.43 cM
• Alliance: Irs4^tm1.1Mfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221293
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of the coding sequence. An additional loxP site was inserted downstream of the coding sequence. Cre-mediated recombination removed the selection cassette and coding sequence. (J:221293)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs4 Mutation: 6 strains or lines available

References

• Original: J:221293 Sadagurski M, et al., Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Mol Metab. 2014 Feb;3(1):55-63
• All: 1 reference(s)