Slit2^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Slit2^tm1.1Ics
• Name: slit guidance ligand 2; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5705113
• Synonyms: Slit2^flox
• Gene: Slit2 Location: Chr5:48140480-48465075 bp, + strand Genetic Position: Chr5, 26.05 cM
• Alliance: Slit2^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exon 8 was floxed. Flp-mediated recombination remvoed the FRT-flanked neomycin resistance cassette. (J:221288, J:228373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slit2 Mutation: 88 strains or lines available

References

• Original: J:221288 Gibson DA, et al., Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells. Neuron. 2014 Mar 5;81(5):1040-56
• All: 7 reference(s)