Slc7a14^em1Jqu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc7a14^em1Jqu
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14; endonuclease-mediated mutation 1, Jia Qu
• MGI ID: MGI:5705135
• Synonyms: Slc7a14^-
• Gene: Slc7a14 Location: Chr3:31257007-31364527 bp, - strand Genetic Position: Chr3, 15.17 cM
• Alliance: Slc7a14^em1Jqu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN targeted endonucelase engineered a 10 bp deletion (CTACAGTGGT) in exon 2 that creates a frameshift and premature stop codon (Thr55Serfs*82). (J:225228, J:323825)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc7a14 Mutation: 42 strains or lines available

References

• Original: J:225228 Jin ZB, et al., SLC7A14 linked to autosomal recessive retinitis pigmentosa. Nat Commun. 2014;5:3517
• All: 3 reference(s)