Pelo^tm2Imad
Targeted Allele Detail

Summary

• Symbol: Pelo^tm2Imad
• Name: pelota mRNA surveillance and ribosome rescue factor; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:5705245
• Synonyms: Pelo^F
• Gene: Pelo Location: Chr13:115224891-115226694 bp, - strand Genetic Position: Chr13, 64.61 cM
• Alliance: Pelo^tm2Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228122
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted into intron 1 and a second loxP site was inserted into the 3-prime flanking region of this gene to create a conditional ready allele in which cre mediated exision will remove exons 2 and 3, which are the coding exons. (J:228122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pelo Mutation: 15 strains or lines available

References

• Original: J:228122 Nyamsuren G, et al., Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling. Stem Cell Res. 2014 Jul;13(1):61-74
• All: 5 reference(s)