Tg(tetO-EGFR*T790M*L858R)51Paow
Transgene Detail
|
Symbol: |
Tg(tetO-EGFR*T790M*L858R)51Paow |
Name: |
transgene insertion 51, William Pao |
MGI ID: |
MGI:5705251 |
Synonyms: |
EGFRL858R+T790M, line 51 |
Transgene: |
Tg(tetO-EGFR*T790M*L858R)51Paow Location: unknown
|
Alliance: |
Tg(tetO-EGFR*T790M*L858R)51Paow page
|
|
|
Transgene Type: |
|
Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) |
Inducer: |
|
doxycycline/tetracycline |
Mutation: |
|
Insertion
|
|
|
Tg(tetO-EGFR*T790M*L858R)51Paow expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
EGFR (1956) |
|
|
|
|
|
Mutation details: A mutant human epidermal factor receptor cDNA with a C-to-T nucleotide substitution in exon 20 that replaces threonine with methionine at amino acid position 790 (T790M) and a T-to-G nucleotide substitution in exon 21 that replaces leucine with arginine at amino acid position 858 (L858R) was cloned between a tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) under control of a tissue-specific promotor can be induced to express the mutant gene in tissues or cell types of interest by administration/withdrawal of doxycycline. Three founders were established: 12, 29, and 51, and line 51 is entered as a representative line.
(J:128700)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:128700 Regales L, et al., Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors. PLoS One. 2007;2(8):e810 |
All: |
4 reference(s) |
|