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Tg(tetO-EGFR*T790M*L858R)51Paow
Transgene Detail
Summary
Symbol: Tg(tetO-EGFR*T790M*L858R)51Paow
Name: transgene insertion 51, William Pao
MGI ID: MGI:5705251
Synonyms: EGFRL858R+T790M, line 51
Transgene: Tg(tetO-EGFR*T790M*L858R)51Paow  Location: unknown  
Alliance: Tg(tetO-EGFR*T790M*L858R)51Paow page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(tetO-EGFR*T790M*L858R)51Paow expresses 1 gene
 
Mutation detailsA mutant human epidermal factor receptor cDNA with a C-to-T nucleotide substitution in exon 20 that replaces threonine with methionine at amino acid position 790 (T790M) and a T-to-G nucleotide substitution in exon 21 that replaces leucine with arginine at amino acid position 858 (L858R) was cloned between a tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) under control of a tissue-specific promotor can be induced to express the mutant gene in tissues or cell types of interest by administration/withdrawal of doxycycline. Three founders were established: 12, 29, and 51, and line 51 is entered as a representative line. (J:128700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(tetO-EGFR*T790M*L858R)51Paow
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:128700 Regales L, et al., Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors. PLoS One. 2007;2(8):e810
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory