Alk^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Alk^tm1.1Ics
• Name: anaplastic lymphoma kinase; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5705324
• Synonyms: Alk^R1279Q
• Gene: Alk Location: Chr17:72175967-72911622 bp, - strand Genetic Position: Chr17, 43.77 cM
• Alliance: Alk^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228124
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 25 was replaced with one in which a point mutation that results in the amino acid substitution of glutamine for arginine at position 1279. This mutation corresponds to the R1275 identified in patients with neuroblastoma. Cre-mediated recombination removed the neomycin resistance cassette inserted downstream of the modified exon. (J:228124)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alk Mutation: 64 strains or lines available

References

• Original: J:228124 Cazes A, et al., Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma. Oncotarget. 2014 May 15;5(9):2688-702
• All: 3 reference(s)