Dmrtb1^tm1.1Zark
Targeted Allele Detail

Summary

• Symbol: Dmrtb1^tm1.1Zark
• Name: DMRT-like family B with proline-rich C-terminal, 1; targeted mutation 1.1, David Zarkower
• MGI ID: MGI:5705340
• Synonyms: Dmrt6^-
• Gene: Dmrtb1 Location: Chr4:107533487-107541427 bp, - strand Genetic Position: Chr4, 50.18 cM, cytoband C7
• Alliance: Dmrtb1^tm1.1Zark page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217504
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 1 via homologous recombination. Cre mediated recombination removed exon 1 and the pgk-neo cassette. (J:217504)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmrtb1 Mutation: 16 strains or lines available

References

• Original: J:217504 Zhang T, et al., The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Development. 2014 Oct;141(19):3662-71
• All: 1 reference(s)