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Tg(hs841-cre/ERT2,-GFP)522Jlr
Transgene Detail
Summary
Symbol: Tg(hs841-cre/ERT2,-GFP)522Jlr
Name: transgene insertion 522, John L R Rubenstein
MGI ID: MGI:5705376
Synonyms: 841-CreER-IRES-GFP
Transgene: Tg(hs841-cre/ERT2,-GFP)522Jlr  Location: unknown  
Alliance: Tg(hs841-cre/ERT2,-GFP)522Jlr page
Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(hs841-cre/ERT2,-GFP)522Jlr expression driven by 1 gene
 
Mutation detailsThis transgene contains the human enhancer element hs841, which is flanked on human Chr 10 by the shootin 1 (SHTN1) and ventral anterior homeobox 1 (VAX1) genes, followed by a minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus. (J:94077)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: hs841 (human)
Summary of all recombinase alleles driven by hs841.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory