Mrln^em1Eno
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mrln^em1Eno
• Name: myoregulin; endonuclease-mediated mutation 1, Eric N Olson
• MGI ID: MGI:5705514
• Synonyms: MLN KO
• Gene: Mrln Location: Chr10:70040494-70055541 bp, + strand Genetic Position: Chr10, 36.68 cM, cytoband B5.2
• Alliance: Mrln^em1Eno page

Mutation origin

• Strain of Origin: (C57BL/6 x C3H)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: TALEN mediated recombination inserted a tdTomato reporter and triple polyadenylation cassette into exon 1. Detection of tdTomato fluorescence was specific to skeletal muscle and was not detected in other tissues, such as tendon. Real-time PCR analysis using primer pairs specific to the downstream exons 2 and 3 confirmed the absence of transcript in skeletal muscle as well as in liver. (J:217579)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrln Mutation: 4 strains or lines available

References

• Original: J:217579 Anderson DM, et al., A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell. 2015 Feb 12;160(4):595-606
• All: 1 reference(s)