Prtn3^tm1.1Hrlu
Targeted Allele Detail

Summary

• Symbol: Prtn3^tm1.1Hrlu
• Name: proteinase 3; targeted mutation 1.1, Hongbo R Luo
• MGI ID: MGI:5705568
• Gene: Prtn3 Location: Chr10:79715499-79719008 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Prtn3^tm1.1Hrlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217636
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2 and an FRT- pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the selection cassette and exon 2. (J:217636)

Generation of the Prtn3^tm1Hrlu and Prtn3^tm1.1Hrlu alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prtn3 Mutation: 13 strains or lines available

References

• Original: J:217636 Loison F, et al., Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation. J Clin Invest. 2014 Oct;124(10):4445-58
• All: 3 reference(s)