Ngly1^tm1Tasuz
Targeted Allele Detail

Summary

• Symbol: Ngly1^tm1Tasuz
• Name: N-glycanase 1; targeted mutation 1, Tadashi Suzuki
• MGI ID: MGI:5705594
• Gene: Ngly1 Location: Chr14:6157837-6220449 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A2
• Alliance: Ngly1^tm1Tasuz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217663
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 11 and an FRT flanked neo cassette and loxP site were inserted downstream of exon12 via homologous recombination. (J:217663)

Generation of the Ngly1^tm1Tasuz and Ngly1^tm1.1Tasuz alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ngly1 Mutation: 39 strains or lines available

References

• Original: J:217663 Huang C, et al., Endo-beta-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1398-403
• All: 2 reference(s)