Gt(ROSA)26Sor^{tm2.1(CAG-Foxn1,-GFP)Cbln}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2.1(CAG-Foxn1,-GFP)Cbln}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, C Clare Blackburn
• MGI ID: MGI:5705813
• Synonyms: iFoxn1, Rosa26^{CAG-STOP-Foxn1-IRES-GFP}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2.1(CAG-Foxn1,-GFP)Cbln} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217716
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2.1(CAG-Foxn1,-GFP)Cbln} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Foxn1

• Mutation details: A construct containing a CAG promoter, loxP site, FRT flanked neo cassette, stop cassette, loxP site, Foxn1 cDNA, IRES and GFP gene was inserted in the locus via homologous recombination. Flp mediated recombination removed the neo cassette. (J:217716)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 997 strains or lines available

References

• Original: J:217716 Bredenkamp N, et al., An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts. Nat Cell Biol. 2014 Sep;16(9):902-8
• All: 4 reference(s)