Dpe1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Dpe1^C57BL/6J
• Name: Der p1 antigen induced pulmonary eosinophils; C57BL/6J
• MGI ID: MGI:5706621
• QTL: Dpe1 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:217518

QTL Reference Notes

The Collaborative Cross (CC) is a large (~1,000 line) panel of recombinant inbred (RI) mouse strains being developed through a community effort (Churchill et al. 2004). The CC combines the genomes of eight genetically diverse founder strains - A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ - to capture nearly 90% of the known variation present in laboratory mice. CC strains are derived using a unique funnel breeding scheme. Once inbred, the RI CC lines can be used to generate thousands of potential 'outbred' but completely reproducible genomes through the generation of recombinant inbred crosses (RIX). The designation 'PreCC' is used to describe a mapping population of CC mice that is still at incipient stages of inbreeding. CTC (2004), Churchill, G. A., et al.. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 36, 1133-7.

Linkage analysis was performed on 151 male PreCC# mice to identify QTL associated with airway eosinophilia. Mice were obtained from Oak Ridge National Laboratory (Oak Ridge, TN). Each mouse was from a distinct CC line that had undergone 514 generations of inbreeding.

QTL Dpe1 maps to 72.9 - 87.1 Mb on Chromosome 11 with a peak LOD score of 7.0 in linkage with airway eosinophilia. C57BL/6J and A/J alleles contribute to the phenotype at the Dpe1 locus. Tlcd2 was identified as a probable candidate gene for the Dpe1 QTL.

References

• Original: J:217518 Kelada SN, et al., Integrative genetic analysis of allergic inflammation in the murine lung. Am J Respir Cell Mol Biol. 2014 Sep;51(3):436-45
• All: 1 reference(s)