Nkx2-5^tm1.1Gum
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm1.1Gum
• Name: NK2 homeobox 5; targeted mutation 1.1, Deborah L Gumucio
• MGI ID: MGI:5706642
• Synonyms: Nkx2-5^fl, Nkx2-5^flox
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm1.1Gum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. (J:228275)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:228275 Udager AM, et al., Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3. Gastroenterology. 2014 Jan;146(1):157-65.e10
• All: 2 reference(s)