Mir92-1^tm1.1Sdim
Targeted Allele Detail

Summary

• Symbol: Mir92-1^tm1.1Sdim
• Name: microRNA 92-1; targeted mutation 1.1, Stefanie Dimmeler
• MGI ID: MGI:5706715
• Gene: Mir92-1 Location: Chr14:115281859-115281938 bp, + strand Genetic Position: Chr14, 59.4 cM
• Alliance: Mir92-1^tm1.1Sdim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218943
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The microRNA sequence was flanked by loxP sites and a neomycin gene flanked by FRT sites. Cre-mediated recombination removed the microRNA sequence. (J:218943)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir92-1 Mutation: 4 strains or lines available

References

• Original: J:218943 Penzkofer D, et al., Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development. PLoS One. 2014;9(6):e101153
• All: 1 reference(s)