E2f4^tm2.1Lees
Targeted Allele Detail

Summary

• Symbol: E2f4^tm2.1Lees
• Name: E2F transcription factor 4; targeted mutation 2.1, Jacqueline A Lees
• MGI ID: MGI:5706731
• Synonyms: E2f4^f
• Gene: E2f4 Location: Chr8:106024295-106032002 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: E2f4^tm2.1Lees page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228346
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced into intron 1 and intron 4. The positive selection cassette used for targeting was removed via FLPe mediated recombination after germline transmission. (J:228346)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any E2f4 Mutation: 21 strains or lines available

References

• Original: J:228346 Danielian PS, et al., E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle. 2016 Jan 17;15(2):250-60
• All: 2 reference(s)