Mllt10^tm1Saam
Targeted Allele Detail

Summary

• Symbol: Mllt10^tm1Saam
• Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10; targeted mutation 1, Scott Armstrong
• MGI ID: MGI:5706747
• Synonyms: Af10^fl
• Gene: Mllt10 Location: Chr2:18060048-18217199 bp, + strand Genetic Position: Chr2, 12.84 cM, cytoband A2
• Alliance: Mllt10^tm1Saam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217454
• Parent Cell Line: CJ9 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• A genomic region including exons 17 and 18 was flanked with loxP sites via homologous recombination. (J:217454)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mllt10 Mutation: 124 strains or lines available

References

• Original: J:217454 Deshpande AJ, et al., AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908
• All: 2 reference(s)